MCAS. Сенсибилизация. Непереносимости пищевые и ОС

Тема в разделе "СХУ не герпетического происхождения", создана пользователем zaika11, 1 янв 2019.

  1. zaika11

    zaika11 Well-Known Member

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    Всем привет! Предлагаю создать отдельную тему, актуальную для многих.
    К сожалению, эта проблема начинается с маленьких вещей- звоночков, но имеет тенденцию к усилению и развитию. И напрямую влияет на усугубление воспаления, развитию аутоимунных заболеваний.

    Данная тема не только про гистамин, а точнее вовсе не про него. А про совокупность ВСЕХ нейромедиаторов воспаления, выделяемых на фоне инфекций - вирусных, бактериальный, пищевых или лекарственных триггеров, интоксикаций, а также воздействия окружающей среды.

    Материал объемный, клинические формы различны. Интересны все формы гипер-реактивности и повышенной чувствительности.

    Аккумулируем мысли, материалы, и личные опыты успешной/безуспешной борьбы с этим
     
  2. zaika11

    zaika11 Well-Known Member

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    Кому интересно, вот так вот любопытный протокол. Так док - пионер по MCAS в штатах диагностирует проблему у СХУ пациентов

    Antibody Tests for ME/CFS Patients

    Cyrex Array 5- Multiple Autoimmune Reactivity Screen


    Parietal Cell+ATPase antibodies
    Intrinsic Factor antibodies
    ASCA+ANCA antibodies
    Tropomyosin antibodies

    Thyro globulin antibodies
    Thyroid Peroxidase antibodies
    21-Hydroxylase(AdrenalCortex) antibodies
    Myocardia lPeptide antibodies
    Alpha-Myosin antibodies
    Phospholipidantibodies
    PlateletGlycoprotein antibodies
    Testisantibodies
    Fibulinantibodies
    CollagenComplexantibodies
    ArthriticPeptideantibodies
    Osteocyteantibodies
    CytochromeP450(Hepatocyte)antibodies
    Insulin+IsletCellantibodies
    GlutamicAcidDecarboxylase65antibodiesMyelinBasicProteinantibodies
    Asialogangliosideantibodies
    Alpha-Tubulin+Beta-Tubulinantibodies
    Cerebellarantibodies
    Synapsinantibodies

    CellTrendCFS/POTSDiagnostic


    Antia-1-adrenergicantibodies
    Antia-2-adrenergicantibodies
    Antib-1-adrenergicantibodies
    Antib-2-adrenergicantibodies
    Anti-muscariniccholinergicreceptor1antibodiesAnti-muscariniccholinergicreceptor2antibodiesAnti-muscariniccholinergicreceptor3antibodiesAnti-muscariniccholinergicreceptor4antibodiesAnti-muscariniccholinergicreceptor5antibodies

    CunninghamPanel

    Anti-DopamineReceptorD1
    Anti-DopamineReceptorD2LAnti-LysogangliosideGM1
    Anti-Tubulin
    CaMKinaseII

    LabCorp

    Anti-MitochondrialAb
    Anti-SmoothMuscleAbAnti-CardiolipinAb
    RheumatoidFactorIgM

    QuestDiagnostics


    Beta2glycoproteinIgG,IgM,IgA
    Lupusanticoagulant
    Anti-phosphatidylserineIgG,IgM,IgA
    Anti-prothrombinIgG(IgMisnotcurrentlyavailableduetoreagentshortage)Anti-phosphatidylserine-prothrombinIgG,IgM
    Anti-AnnexinVIgG,IgM
    Anti-phosphatidylethanolamineIgG,IgM
    ANAbyIFA
    ENA
    SS-A
    SS-B
    AntiTTGIgA
    AntiGliadin

    MAYOAutoimmuneDysautonomia


    Striational(StriatedMuscle)Ab,S
    Anti-NeuronalNuclearAb,Type1
    N-TypeCalciumChannelAb
    AchReceptor(Muscle)MindingAbAcChRGanglionicNeuronalAb,SNeuronal(V-G)K+ChannelAb,S

    GAD65AbAssay,S

    P/QTypeCalciumChannelAbMAYOAutoimmuneEncephalitis


    NMDA-R,AbCBA,S
    Neuronal(V-G)K+ChannelAb,SLG1-IgGCBA,S
    CASPR2-IgGCBA,S
    GABA8-RAbCBA,S
    AMPA-RAb,CBA,S
    ANNA-1,S
    ANNA-2,S
    AGNA-1,S
    PCA-1,S
    PCA-2,S
    PCA-Tr,S
    AmphiphysinAb,S
    AChReceptor(muscle)BindAb
    CRMP5-IgG,S


    поехал текст -прикреплю исходник
     
    Последнее редактирование: 1 янв 2019
    ИванZ нравится это.
  3. zaika11

    zaika11 Well-Known Member

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    Mechanisms of actions for high dose IVIG:

    1) Functional blockade of immunoglobulin E receptors on mast cell membranes.

    2) Inhibition of complement mediated damage and modulation of the cytokines/cytokine antagonists’ production. Decreasing Th2 dominance.

    3) Neutralization of circulating autoantibodies (if I have autoantibodies) by anti-idiotypic antibodies present in high-dose intravenous immunoglobulin.

    4) An additional trigger for mast cell activation includes T-cell activity and release of microparticles and cytokines. IVIG increases regulatory T-cells which could reduce T-cell activity and thereby reduce mast cell activity.

    5) IgG has been found to downregulate IgE bound to mast cells and thus binding IgG by IVIG could play an additional role.

    6) Increases glucocorticoid sensitivity (thus decreasing steroid dosage needed and may help with autonomic dysfunction): IVIG increases glucocorticoid receptor binding may occur indirectly, since IVIG decreases production of the two cytokines known to alter glucocorticoid receptor binding – IL‐2 and IL‐4.

    7) Administration of high‐dose IVIG may provide circulating antibodies which bind to IgE and remove them from the circulation.

    8) IVIG at high doses has many more anti‐inflammatory and immunomodulatory effects

    ***

    Sources for #1-4: “Successful treatment of postural orthostatic tachycardia and mast cell activation syndromes using naltrexone, immunoglobulin and antibiotic treatment” (https://casereports.bmj.com/content/casereports/2018/bcr-2017-221405.full.pdf)

    “Solar urticaria treated successfully with intravenous high-dose immunoglobulin: a case report” (full paper attached)

    Source for #5: “IgG-mediated down-regulation of IgE bound to mast cells: a potential novel mechanism of allergen-specific desensitization” (full paper attached)

    Source for #6 and 7: The role of immunoglobulin therapy in allergic diseases (https://onlinelibrary.wiley.com/doi/full/10.1034/j.1398-9995.1999.00094.x)


    Other studies relating to mechanisms:

    “Effect of high-dose intravenous immunoglobulin treatment in therapy-resistant chronic spontaneous urticaria” (Full paper attached)

    “Role of Treg in immune regulation of allergic diseases” (Full paper attached)

    “High‐dose, but not low‐dose, IVIg treatment enhanced the activation status of circulating Tregs” (https://onlinelibrary.wiley.com/doi/full/10.1111/cei.12102)

    "The IgG molecule as a biological immune response modifier: Mechanisms of action of intravenous immune serum globulin in autoimmune and inflammatory disorders" (Full paper attached) (More mechanisms, pg 3)
     
    Живой и Aves нравится это.
  4. Виолетта

    Виолетта Админ Команда форума

    Регистрация:
    9 дек 2015
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    более половины анализов не делают у нас. либо названия одного и того же разные.
     

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